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Volume regulation in astrocytes: A role for taurine as an osmoeffector

✍ Scribed by H. Pasantes Morales; A. Schousboe

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
512 KB
Volume
20
Category
Article
ISSN
0360-4012

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✦ Synopsis

Astrocytes in culture regulate their volume under anisosmotic conditions by as yet unclear mechanisms. In a number of other cells this process involves a loss of intracellular osmotically active solutes, including taurhe. The possibility that taurine participates as an osmoeffector in astrocytes was examined in cultured astrocytes exposed to hyposmolar conditions.

Astrocytes responded to decreases in osmolarity by rapid swelling followed by a volume regulatory phase. Hyposmotic conditions induced a dramatic increase of 3H-taurine efflux, with a time course corresponding to the cell volume regulatory phase. Decreasing osmolarity from 310 to 254, 198 or 150 m osmoles resulted in the release of 8.2%, 17%, and 54%, respectively, of 3Htaurine previously accumulated by astrocytes. Endogenous taurine concentration decreased 64%. The efnux of 3-H GABA, 3H-glycine, or 3H-D-aspartate was much less affected under similar conditions. These results suggest a role for taurine as an osmoeffector in astrocytes.

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