Voltammetric Oxidation of Ambroxol and Application to Its Determination in Pharmaceuticals and in Drug Dissolution Studies

✍ Scribed by B. Tolga Demircigil; Bengi Uslu; Yalçin Özkan; Sibel A. Özkan; Zühre Sentürk

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 84 KB
• Volume: 15
• Category: Article
• ISSN: 1040-0397
• DOI: 10.1002/elan.200390029

✦ Synopsis

Abstract

A detailed study of the electrochemistry of ambroxol at a glassy carbon electrode was carried out in the pH range 1.8–11.0 in aqueous solution using cyclic and differential pulse voltammetry. The compound was oxidized irreversibly at high positive potentials resulting in the formation of a chemical product at less positive potentials, which was more readily oxidized than the parent compound. In addition, a differential pulse voltammetric method was proposed for the determination of the drug in different pharmaceutical formulations, and in drug dissolution studies.