Voltammetric Behavior of Fluvoxamine Using Square-Wave and Adsorptive Stripping Square-Wave Techniques. Determination in Pharmaceutical Products

✍ Scribed by J. J. Berzas Nevado; J. Rodriguez Flores; G. Castañeda Peñalvo

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 104 KB
• Volume: 12
• Category: Article
• ISSN: 1040-0397
• DOI: 10.1002/1521-4109(200009)12:13<1059::aid-elan1059>3.0.co;2-o

✦ Synopsis

The behavior of ¯uvoxamine (FVX) was studied by square-wave techniques, leading to two methods for its determination in aqueous samples (pH 2.0 and 4.7) and pharmaceuticals formulations. The application of the square-wave mode shows the determination of FVX between 2610 78 and 3610 76 mol L 71 . FVX gave an adsorptive stripping voltammetric peak at the hanging mercury drop electrode at 7 0.76 V, using an accumulation potential of 7 0.50 V. By the stripping technique, FVX proved to be more sensitive, yielding signals ®ve times larger than those obtained by applying a square-wave scan without the previous accumulation. The calibration plot to determine FVX was linear in the range 5610 79 and 1610 76 mol L 71 by stripping mode. The relative standard deviations obtained for concentration levels of FVX as low as 1.5610 76 mol L 71 with square-wave was 3.54 % (n 10) and for 6.0610 77 mol L 71 with stripping square-wave was 2.39 % (n 10) in the same day. The two proposed methods (SW and SWAdSV) were applied to the determination of ¯uvoxamine in two Spanish commercial product (Dumirox 50 and Dumirox 100) with very good recoveries respect to the labelled values.