Voltammetric and differential pulse determination of roxithromycin

✍ Scribed by K.M. Drljević-Djurić; V.D. Jović; U.Č. Lacnjevac; M.L. Avramov Ivić; S.D. Petrović; D.Ž. Mijin; S.B. Djordjević

• Book ID: 103828365
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 225 KB
• Volume: 56
• Category: Article
• ISSN: 0013-4686
• DOI: 10.1016/j.electacta.2010.09.067

✦ Synopsis

The oxidative behavior of antibiotic roxithromycin standard was studied at a gold electrode in 0.05 M NaHCO 3 using cyclic linear sweep voltammetry and differential pulse voltammetry. It was found that the value of the oxidative peak of pure roxithromycin at 0.81 V vs. SCE in 0.05 M NaHCO 3 at a scan rate of 50 mV s -1 is a linear function of the concentration in a range 0.10006-0.654 mg cm -3 . It was also found that peak current density at 0.75 V vs. SCE at a scan rate of 2 mV s -1 , pulse amplitude of 25 mV and pulse time of 0.1 s exhibits linear dependence on the concentration of roxithromycin from 0.1006 to 0.476 mg cm -3 . Roxithromycin as a content of solid dosage form and urine was quantitatively determined and the obtained results were checked by HPLC.