Voltammetric analysis of polyisoprenoid-containing bilayer lipid membranes

✍ Scribed by Tadeusz Janas; Janina Kuczera; Tadeusz Chojnacki

• Publisher: Elsevier Science
• Year: 1989
• Tongue: English
• Weight: 822 KB
• Volume: 51
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(89)90010-8

✦ Synopsis

Voltammetric investigations of bilayer lipid membranes modified by polyisoprenols (PI) and phosphopolyisoprenols (phospho-PI) are described. The theoretical background of voltammetric analysis with application to a system is presented. It is shown that contrary to the behaviour of phospho-PI, PI increases membrane permeability and membrane deformability, decreases the activation energy of ionic transmembrane migration, decreases membrane stability and does not change membrane selectivity. The results also indicate that a transmembrane potential can facilitate the formation of local non-bilayer structures in dolichyl phosphate-phosphatidylcholine bilayer membrane and accelerate the transbilayer movement of the polar part of a dolichyl phosphate molecule. Our hypothesis of PI and phospho-PI ordering, dynamics and function in membranes is presented.