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Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins

โœ Scribed by Sho-Ya Wang; Ging Kuo Wang

Book ID
114283758
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
246 KB
Volume
15
Category
Article
ISSN
0898-6568

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This study was undertaken to assess the binding properties of BmK AS on both mammal and insect excitable cell membranes. It was found that BmK AS bound specifically to a single class of non-interacting binding sites on both rat brain and cockroach nerve cord synaptosomes with high affinity (K d ฯญ 1.