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Voltage-dependent potassium currents in cultured trout oligodendrocytes

✍ Scribed by G. Glassmeier; Dr. G. Jeserich; T. Krüppel

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
720 KB
Volume
32
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Ionic currents were recorded in cultured oligodendrocytes from the brain of trout using the whole‐cell configuration of the patch‐clamp technique. Outward currents were evoked at membrane potentials more positive than −40 mV, which could be separated into two components according to their kinetic parameters and their sensitivity to the holding potential: a fast inactivating current which was completely suppressed by 4‐aminopyridine and reduced by tetraethylammonium and a slow steady‐state conductance which was similarly sensitive to both potassium channel blockers. The current reversal potential was close to the potassium equilibrium potential. In contrast to mammalian oligodendrocytes but in similarity with cultured Schwann cells, trout oligodendrocytes did not exhibit any inwardly rectifying currents at hyperpolarized membrane potentials. © 1992 Wiley‐Liss, Inc.

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