Voltage dependent calcium channels in cerebellar granule cell primary cultures
β Scribed by O. Moran; F. Lin; O. Zegarra-Moran; M. Sciancalepore
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 794 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1432-1017
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Using subtype-specific Ca-channel blockers, we have characterised the voltage-sensitive Ca 21 currents as well as neurotransmitter release from cultured mouse cerebellar granule cells. The whole cell version of the patch clamp technique was adapted to monitor the isolated Ca-channel currents. The cu
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The properties of depolarizationevoked calcium transients are known to change during the maturation of dissociated cerebellar granule neuron cultures. Here, we assessed the role of the calciuminduced calcium release (CICR) mechanism in granule neuron maturation. Both depletion of intracellular calci
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