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Voltage-dependent block by tetrodotoxin of the sodium channel in rabbit cardiac Purkinje fibers

✍ Scribed by Carmeliet, E.


Book ID
118518931
Publisher
Biophysical Society
Year
1987
Tongue
English
Weight
726 KB
Volume
51
Category
Article
ISSN
0006-3495

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Use dependence of sodium current inhibit
✍ Roland Eickhorn; JΓΆrg Weirich; Daniela Hornung; Hermann Antoni πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 943 KB

Tetrodoxin (TTX) is known to cause a voltageand frequency-dependent inhibition of the rapid inward sodium current (IN,) of cardiac muscle. This effect was studied by means of the loose-patch-clamp method on intact rat papillary muscle. The availability curve of the fast sodium system, determined by