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Voltage-dependence of GABAA-receptor desensitization in cultured chick cerebral neurons

โœ Scribed by John J. Hablitz

Book ID
104600450
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
310 KB
Volume
12
Category
Article
ISSN
0887-4476

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โœ Mohammad H. Jalilian Tehrani; John J. Hablitz; Dr. Eugene M. Barnes Jr ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 705 KB

During prolonged application of GABA to cultured neurons from the chick embryo cerebrum, whole-cell voltage-clamp recordings show a decline in GABAgated chloride currents due to desensitization. At a holding potential of -60 mV, desensitization can normally be described as a single exponential proce