Volatile Antiallergic Principles from a Traditional Herbal Prescription of Kampo Medicine
✍ Scribed by Shigeo Tanaka; Makoto Akimoto; Yukihiro Tambe; Mamoru Tabata; Yasumasa Ikeshiro
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 428 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
An aqueous extract of the traditional herbal prescription, Zyumi-Haidoku-San-Ka-Rengyo (ZSR), was examined for antiallergic activity. Its oral administration to rats significantly inhibited homologous passive cutaneous anaphylaxis (PCA) induced by ovalbumin. The bioassay-directed fractionation of the extract followed by GCWS analysis revealed that maryophyllene, a sesquiterpenoid component of the oil, was four times as active as the antiallergic drug tranilast against PCA induced in the ears of mice. PCaryophyllene proved to be more effective than its structural isomer, a-humulene (ru-caryophyllene), suggesting that the peculiar bicyclic system with fourand nine-member rings is of importance in enhancing the antiallergic activity of the sesquiterpene molecule.