Vocal fold augmentation with calcium hydroxylapatite: Twelve-month report

✍ Scribed by Clark A. Rosen; Jackie Gartner-Schmidt; Roy Casiano; Timothy D. Anderson; Felicia Johnson; Marc Remacle; Robert T. Sataloff; Jean Abitbol; Gary Shaw; Sanford Archer; Richard I. Zraick

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 177 KB
• Volume: 119
• Category: Article
• ISSN: 0023-852X
• DOI: 10.1002/lary.20126

✦ Synopsis

Abstract

Objectives:

To evaluate the long‐term effectiveness of calcium hydroxylapatite (CaHA) vocal fold injection for patients with glottal insufficiency.

Study Design:

Multicenter, open‐label, prospective clinical study of CaHA vocal fold injection.

Methods:

Each patient served as his/her own control. Voice‐related outcome measures were collected for pre‐injection, 1, 3, 6, and 12 months.

Results:

Sixty‐three patients were available for evaluation. Fifty‐three percent of the injection procedures were done in the office. Fifty‐seven percent of patients were diagnosed with unilateral paralysis and 43% with glottal incompetence with mobile vocal folds. Patient satisfaction 12 months after injection showed 67% reporting a significant improvement in voice and 81% reporting at least a moderate improvement in voice. Utilizing the Voice Handicap Index–10, visual analog scale (vocal effort), Consensus Assessment Perceptual Evaluation V (judgments of voice severity), and objective voice measures of glottal closure (maximum phonation time and S:Z ratio), paired t tests showed significant improvements after treatment. A 22% further treatment rate was found at the 12‐month time point.

Conclusions:

One‐year results in this large cohort of patients with glottal incompetence treated with CaHA vocal fold injection demonstrate that excellent clinical results were achieved. Laryngoscope, 2009