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Vitamin E Synthesis of α-Tocopherol

✍ Scribed by BERGEL, F.; JACOB, A.; TODD, A. R.; WORK, T. S.


Book ID
109524629
Publisher
Nature Publishing Group
Year
1938
Tongue
English
Weight
196 KB
Volume
142
Category
Article
ISSN
0028-0836

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Synthesis of α-Tocopherol (Vitamin E)
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The synthesis of C-13 labeled vitamin E,
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12 '-13C] aZZ-rac-a-Tocopherol (L) was synthesized from [2-13C] acetone. The condensation of 6-methoxymethoxy-2,5,7,8-tetramethyl-2-(5-mercaptothiazolinyl-4-methyl-3-penten-1-y1)chroman (S) with [7-Clgeranyl bromide (11, which was prepared by the coupling of (6-benzoyloxy--4-methyl-4-hexenyl)triphen