๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Vitamin E Supplementation of Smokers and Non-Smokers

โœ Scribed by Duthie, G. G. ;Arthur, J. R.

Publisher
John Wiley and Sons
Year
1990
Weight
325 KB
Volume
92
Category
Article
ISSN
0931-5985

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โœฆ Synopsis

Twenty male smokers and 20 non-smokers took either vitamin E capsules (1000IU/day) or placebo for 14 days. Erythrocytes from smokers showed a marked tendency to peroxidise in uitro compared with non-smokers, an effect which was abolished by vitamin E supplementation. The increased erythrocyte peroxidation may reflect a lipid hydroperoxide-induced decrease in glucose-&phosphate dehydrogenase activity. Evidence that smokers incurred a sustained oxidant stress also included increased plasma conjugated dienes, decreased plasma vitamin C and an increase in erythrocyte glutathione. Plasma cholesterol, vitamin E and conjugated dienes increased with age in all groups. Results suggest that smokers are under a sustained oxidant stress, some indices of which can be partially ameliored by vitamin E supplementation.

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