Vitamin D receptor and analogs
β Scribed by Dusso, Adriana S; Thadhani, Ravi; Slatopolsky, Eduardo
- Book ID
- 123040634
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 133 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0270-9295
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We and others have previously shown that selected vitamin D analogs potentiate the vitamin D receptor (VDR) mediated transcription much more efficiently than the natural hormone itself. Here we show that the transcriptionally active 20-epi analogs, namely KH 1060 and MC 1288, protect VDR against deg
A series of analogs of 1,25-dihydroxycholecalciferol was obtained with an additional chiral center at the terminus of the aliphatic side chain (C-25). The analogs were obtained from (+)-(R)-and (-)-(S)-2-methylglycidols, by opening of the oxirane ring with the carbanions derived from vitamin D C 23a