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Vitamin D receptor alleles and bone physiology

✍ Scribed by C. P. White; N. A. Morrison; E. M. Gardiner; J. A. Eisman

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 786 KB
Volume: 56
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240560306

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The vitamin D endocrine system is central to the control of bone and calcium homeostasis. The active hormonal aform of vitamin D, 1,25 dihydroxyvitamin D (calcitriol), the circulating level of which is tightly regulated, acts through a specific receptor to mediate its genomic actions on almost every aspect of calcium homeostasis. Because of its transactivation function, it possible that a small difference in vitamin D receptor level could be amplified into a biologically significant alteration in physiological setpoint. The recent finding that polymorphisms in the vitamin D receptor gene are predictive of bone density (morrison et al., Nature 367:284–287, 1994) is the first example of an allelic effect in such a homeostatically controlled system. This raises the possibility that such central operators may exist in other regulatory pathways, and could expllain a large part of the observed “ormal” population distribution that exists for all physiological paraameters.

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