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Vitamin D Metabolites Activate the Sphingomyelin Pathway and Induce Death of Glioblastoma Cells

✍ Scribed by L. Magrassi; L. Adorni; G. Montorfano; S. Rapelli; G. Butti; B. Berra; G. Milanesi


Book ID
106205767
Publisher
Springer Vienna
Year
1998
Tongue
English
Weight
182 KB
Volume
140
Category
Article
ISSN
0001-6268

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Betuletol 3-methyl ether induces G2-M ph
✍ Sara Rubio; JosΓ© Quintana; JosΓ© L. Eiroa; Jorge Triana; Francisco EstΓ©vez πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 365 KB

Betuletol 3-methyl ether (BME) is a natural phenylbenzo-gamma-pyrone that inhibits cell proliferation in human tumor cell lines and induces apoptotic cell death in HL-60 cells. Here we show that BME displays strong cytotoxic properties in several human leukemia cell lines (U937, K-562, THP-1, Jurkat