Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure
✍ Scribed by Yan Chun Li; Guilin Qiao; Milan Uskokovic; Wei Xiang; Wei Zheng; Juan Kong
- Book ID
- 116697305
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 97 KB
- Volume
- 89-90
- Category
- Article
- ISSN
- 0960-0760
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## Abstract The renin–angiotensin system (RAS) plays a central role in the regulation of blood pressure, electrolyte, and volume homeostasis. Epidemiological and clinical studies have long suggested an association of inadequate sunlight exposure or low serum 1,25‐dihydroxyvitamin D~3~ [1,25(OH)~2~D
Vitamin D deficiency has been linked to hypertension and an increased prevalence of cardiovascular risk factors and disease. Studies in vitamin D receptor knockout (VDR KO) mice revealed an overstimulated renin-angiotensin system (RAS) and consequent high blood pressure and cardiac hypertrophy. VDR