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Vitamin B12 levels in whole blood, plasma, and blood cells in transplantable rat leukaemias

โœ Scribed by M. Bonelli; L. M. Rinaldini

Publisher
John Wiley and Sons
Year
1967
Tongue
French
Weight
449 KB
Volume
2
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Vitamin Blz levels in whole blood, plasma, and red and white cells were determined by microbiological assay in normal and leukaemic A x C inbred rats. The concentration of B I Z in white cells was 200 to 300 times higher than in red cells in both groups.

A marked increase in the B12 content of whole blood was observed in the leukaemic animals which was ofthe same order of magnitude as the increase in the number of white C<' 11s.

The concentration of BI2 in red cells was the same in normal and leukaemic blood, That in plasma and white cells was only slightly increased in leukaemia. Therefore, the overall increase in blood B1! is attribtttahle t o the increase in the nuniber of white cells in the Ieukaemic animals.

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