Molecular and functional comparison of 1
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Peter W. Jurutka; Paul D. Thompson; G. Kerr Whitfield; Kristina R. Eichhorst; Ne
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Article
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2005
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John Wiley and Sons
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English
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The vitamin D receptor (VDR) binds to and mediates the effects of the 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) hormone to alter gene transcription. A newly recognized VDR ligand is the carcinogenic bile acid, lithocholic acid (LCA). We demonstrate that, in HT-29 colon cancer cells, both LCA and 1