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Visualizing PI3 Kinase-Mediated Cell-Cell Signaling during Dictyostelium Development

✍ Scribed by Dirk Dormann; Gerti Weijer; Carole A. Parent; Peter N. Devreotes; Cornelis J. Weijer

Book ID
114319272
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
650 KB
Volume
12
Category
Article
ISSN
0960-9822

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## Abstract PI 3‐kinase enhancer (PIKE) is a nuclear GTPase that enhances PI 3‐kinase (PI3K) activity. Nerve growth factor (NGF) treatment leads to PIKE activation by triggering the nuclear translocation of PLC‐γ1, which acts as a physiological guanine nucleotide exchange factor (GEF) for PIKE. PI3