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Visualizing new dimensions in Drosophila myoblast fusion

✍ Scribed by Brian Richardson; Karen Beckett; Mary Baylies

Book ID
101706387
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
182 KB
Volume
30
Category
Article
ISSN
0265-9247

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✦ Synopsis

Abstract

Over several years, genetic studies in the model system, Drosophila melanogastor, have uncovered genes that when mutated, lead to a block in myoblast fusion. Analyses of these gene products have suggested that Arp2/3‐mediated regulation of the actin cytoskeleton is crucial to myoblast fusion in the fly. Recent advances in imaging in Drosophila embryos, both in fixed and live preparations, have led to a new appreciation of both the three‐dimensional organization of the somatic mesoderm and the cell biology underlying myoblast fusion. BioEssays 30:423–431, 2008. © 2008 Wiley Periodicals, Inc.

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## Abstract During myogenesis in __Drosophila__ embryos, a prominent adhesive structure is formed between precursor cells and fusion‐competent myoblasts (fcms). Here, we show that Duf/Kirre and its interaction partners Rols7 (found in founder myoblasts and growing myotubes) and Sns (found in fcms)