Visual Transduction and Non-Visual Light Perception

✍ Scribed by George Ayoub (auth.), Joyce Tombran-Tink PhD, Colin J. Barnstable DPhil (eds.)

• Publisher: Humana Press
• Year: 2008
• Tongue: English
• Leaves: 496
• Series: Ophthalmology Research
• Edition: 1
• Category: Library

✦ Synopsis

Remarkable advances have contributed to revolutionizing the study of vertebrate vision. The first step to identifying objects and establishing spatial relationships is the visual transduction cascade, a process that underpins a wide range of ocular diseases and therapies. Toward that, Visual Transduction And Non-Visual Light Perception reveals not only how the eye evolved into an organ of vision, but also describes how molecular mechanisms of key molecules (such as transducins, phosphodiesterases, and CyclicGMP metabolizing enzymes) operate in the phototransduction cascade. In this groundbreaking text, experts also explain mechanisms for sensing readiation outside of the visible wavelengths -- a good example of the limitations of the human sensory systems. Comprehensive and penetrating, Visual Transduction And Non-Visual Light Perception brings together the developmental, structural, and molecular mechanisms of the visual transduction cascade and is an invaluable text for everyone conducting research in the visual system.

✦ Table of Contents

Front Matter....Pages i-x
An Organ of Exquisite Perfection....Pages 3-13
Development of the Foveal Specialization....Pages 17-33
An Update on the Regulation of Rod Photoreceptor Development....Pages 35-64
Photoreceptor—RPE Interactions....Pages 67-86
Molecular Biology of IRBP and Its Role in the Visual Cycle....Pages 87-122
Regulation of Photoresponses by Phosphorylation....Pages 125-140
The cGMP Signaling Pathway in Retinal Photoreceptors and the Central Role of Photoreceptor Phosphodiesterase (PDE6)....Pages 141-169
Rhodopsin Structure, function, and Involvement in Retinitis Pigmentosa....Pages 171-196
Multiple Signaling Pathways Govern Calcium Homeostasis in Photoreceptor Inner Segments....Pages 197-223
The Transduction Channels of Rod and Cone Photoreceptors....Pages 225-249
Rhodopsins in Drosophila Color Vision....Pages 251-266
INAD Signaling Complex of Drosophila Photoreceptors....Pages 267-284
Visual Signal Processing in the Inner Retina....Pages 287-304
Human Cone Spectral Sensitivities and Color Vision Deficiencies....Pages 307-327
Luminous Efficiency Functions....Pages 329-351
Cone Pigments and Vision in the Mouse....Pages 353-373
Multifocal Oscillatory Potentials of the Human Retina....Pages 375-388
The Aging of the Retina....Pages 391-402
Aging of the Retinal Pigment Epithelium....Pages 403-420
Visual Transduction and Age-Related Changes in Lipofuscin....Pages 421-462
A Nonspecific System Provides Nonphotic Information for the Biological Clock....Pages 465-480
The Circadian Clock: Physiology, Genes, and Disease....Pages 481-499
Back Matter....Pages 501-509

✦ Subjects

Ophthalmology; Cell Biology; Molecular Medicine