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Visual Outcomes in Children With Neurofibromatosis Type 1 and Orbitotemporal Plexiform Neurofibromas

✍ Scribed by Avery, Robert A.; Dombi, Eva; Hutcheson, Kelly A.; Acosta, Maria T.; Baldwin, Andrea M.; Madigan, William P.; Gillespie, Andrea; FitzGibbon, Edmond J.; Packer, Roger J.; Widemann, Brigitte C.


Book ID
122812696
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
772 KB
Volume
155
Category
Article
ISSN
0002-9394

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Neurofibromatosis 1 (NF1) is an autosomal dominant disorder caused by genetic alterations of the NF1 gene on 17q11.2. About 30% of NF1 patients develop plexiform neurofibromas (PNFs), which often cause severe clinical deficits. To determine whether there is a certain genotype underlying PNFs or subt