As target-carrier, holotransferrin (Tf) was conjugated with dihydroartemisinin (DHA) to form a new targeted drug. An analog of DHA, 4-(12-dihydroartemisininoxy) benzoic acid hydrazide (DBAH) have been synthesized and characterized by UV/vis spectroscopy, IR spectroscopy, NMR, and electrochemistry. P
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Visual characterization of targeted effect of holo-transferrin-tagged dihydroartemisinin on human breast cancer cells
β Scribed by WeiLing Xie; PeiHui Yang; Xin Zeng; Hui Wang; HuaiHong Cai; JiYe Cai
- Book ID
- 107372175
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 952 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1001-6538
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Since estrogens play a predominant role in the development and growth of human breast cancer, antiestrogens represent a logical approach to the treatment of this disease. The present study compares the effects of the novel nonsteroidal anti-estrogen EM-800 and related compounds with those of a serie