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Viscoeldstic properties of pharmaceutical semisolids III: Nondestructive oscillatory testing

✍ Scribed by Stanley S. Davis

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 564 KB
Volume: 60
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600600913

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✦ Synopsis

0 Semisolid ointments and creams were examined by nondestructive oscillato1 y methods, using the Weissenberg rheogoniometer and a digital transfer function analyser. Fundamental rheological parameters (v', G', and C " ) were measured over the frequency range from 2.5 X 10-4 to 25 Hz. The variation with frequency of the loss tangent (a ratio of viscous to elastic contributions) provides a useful "consistency spectrum" for characterization of pharmaceutical products. The shapes of spectra and the magnitudes of the loss tangent are discussed with relation to seven ointments and four creams. A comparison of oscillatory and transient (creep) methods is also made.

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