Virus-free induction of pluripotency and subsequent excision of reprogramming factors
β Scribed by Kaji, Keisuke; Norrby, Katherine; Paca, Agnieszka; Mileikovsky, Maria; Mohseni, Paria; Woltjen, Knut
- Book ID
- 109898079
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 918 KB
- Volume
- 458
- Category
- Article
- ISSN
- 0028-0836
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## Abstract Ectopic expression of a defined set of transcription factors chosen from Oct3/4, Sox2, cβMyc, Klf4, Nanog, and Lin28 can directly reprogram somatic cells to pluripotency. These reprogrammed cells are referred to as induced pluripotent stem cells (iPSCs). To date, iPSCs have been success
## Abstract Somatic cells can be reprogrammed toward pluripotency by overexpression of a set of transcription factors, yielding induced pluripotent stem cells (iPSCs) with features similar to embryonic stem cells. Little is known to date about stoichiometric requirements of the individual reprogram