𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Virus Dynamics: the Effect of Target Cell Limitation and Immune Responses on Virus Evolution

✍ Scribed by Roland R. Regoes; Dominik Wodarz; Martin A. Nowak

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
279 KB
Volume
191
Category
Article
ISSN
0022-5193

No coin nor oath required. For personal study only.

✦ Synopsis

Earlier models of virus evolution during single infections do not include target cell limitation. Here we extend the basic mathematical framework of these theories and study the effect of target cell limitation on the evolution of antigenic variation, increasing replication rates and increasing virus load. We find that target cell limitation provides a selection pressure against antigenic diversification, and can therefore provide a limit to diversity. Antigenic diversity increases virus load; at the maximum level of antigenic diversity, virus load, too, is at a maximum.

πŸ“œ SIMILAR VOLUMES

Temporal regulation of influenza hemaggl
Temporal regulation of influenza hemagglutinin expression in vaccinia virus recombinants and effects on the immune response
✍ Barbara E. H. Coupar; Marion E. Andrew; Gerald W. Both; David B. Boyle πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 909 KB

and Division of Molecular Biology', CSIRO, North Ryde ## Temporal regulation of influenza hemagglutinin expression in vaccinia virus recombinants and effects on the immune response* Regulation of the expression of influenza AIPW8134 hemagglutinin (HA) by the vaccinia virus promoters PF (early), P

Effect of immune pressure on hepatitis C
Effect of immune pressure on hepatitis C virus evolution: Insights from a single-source outbreak
✍ Shahzma Merani; Danijela Petrovic; Ian James; Abha Chopra; Don Cooper; Elizabeth πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 489 KB

The host's immune response to hepatitis C virus (HCV) can result in the selection of characteristic mutations (adaptations) that enable the virus to escape this response. The ability of the virus to mutate at these sites is dependent on the incoming virus, the fitness cost incurred by the mutation,

Role of apoptosis in the regulation of v
Role of apoptosis in the regulation of virus-induced T cell responses, immune suppression, and memory
✍ Raymond M. Welsh; Liisa K. Selin; Enal S. Razvi πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English

## Abstract Apoptosis is an important mechanism enabling the selection of the non‐self‐reactive T cell repertoire and for maintaining homeostasis in the immune system after it has expanded to combat infections. Highly activated, proliferating T cells become susceptible to apoptosis driven by a numb

Tumor necrosis factor alpha inhibits the
Tumor necrosis factor alpha inhibits the suppressive effect of regulatory T cells on the hepatitis B virus–specific immune response
✍ Jeroen N. Stoop; Andrea M. Woltman; Paula J. Biesta; Johannes G. Kusters; Ernst πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 264 KB πŸ‘ 1 views

## Chronicity of hepatitis B virus (HBV ) infection is characterized by a weak immune response to the virus. CD4 Ψ‰ CD25 Ψ‰ regulatory T cells (Treg) are present in increased numbers in the peripheral blood of chronic HBV patients, and these Treg are capable of suppressing the HBV-specific immune re

Cell-mediated and humoral immune respons
Cell-mediated and humoral immune responses to tumor-associated and viral antigens in relation to the pathogenic effect of rous sarcoma virus in rats
✍ Nils Jonsson πŸ“‚ Article πŸ“… 1971 πŸ› John Wiley and Sons 🌐 French βš– 660 KB

## Abstract After inoculation of the Schmidt‐Ruppin strain of Rous sarcoma virus (SR‐RSV) into a series of newborn rats (strain R/F) sarcomas developed in 47% of the animals, half of which also had hemorrhagic‐cystic lesions. In 18% such hemorrhagic cysts occurred without demonstrable tumors, while