✦ LIBER ✦

Virtual Screening Studies to Design Potent CDK2-Cyclin A Inhibitors.

✍ Scribed by S. Vadivelan; Barij Nayan Sinha; Sheeba Jem Irudayam; Sarma A. R. P. Jagarlapudi

Publisher: John Wiley and Sons
Year: 2007
Weight: 11 KB
Volume: 38
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200741203

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A Practical Synthesis of the Major 3-Hyd

A Practical Synthesis of the Major 3-Hydroxy-2-pyrrolidinone Metabolite of a Potent CDK2/Cyclin A Inhibitor.

✍ Marcella Nesi; Daniela Borghi; Maria Gabriella Brasca; Francesco Fiorentini; Pao 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 14 KB 👁 1 views

Synthesis of 3-(1H-Benzimidazol-2-yl)-5-

Synthesis of 3-(1H-Benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a Potent Cyclin Dependent Kinase 1 (CDK1) Inhibitor.

✍ Shenlin Huang; Ronghui Lin; Yang Yu; Yanhua Lu; Peter J. Connolly; George Chiu; 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

New Scoring Functions for Virtual Screen

New Scoring Functions for Virtual Screening from Molecular Dynamics Simulations with a Quantum-Refined Force-Field (QRFF-MD). Application to Cyclin-Dependent Kinase 2.

✍ Ph. Ferrara; A. Curioni; E. Vangrevelinghe; T. Meyer; T. Mordasini; W. Andreoni; 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 8 KB

From Hit to Lead: De Novo Design Based o

From Hit to Lead: De Novo Design Based on Virtual Screening Hits of Inhibitors of tRNA-Guanine Transglycosylase, a Putative Target of Shigellosis Therapy

✍ Ruth Brenk; Hans-Dieter Gerber; Jeffrey D. Kittendorf; George A. Garcia; Klaus R 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 299 KB

## Abstract Shigellosis, a bacterial disease, causes the death of more than one million people per year. Extensive studies of __Shigella flexneri__ have recognized tRNA‐guanine transglycosylase (TGT, EC 2.4.2.29) as one of the key enzymes involved in the regulation of bacterial virulence. Based on

Inhibition of Secretory Phospholipase A2

Inhibition of Secretory Phospholipase A2. Part 1. Design, Synthesis and Structure—Activity Relationship Studies Starting from 4-Tetradecyloxybenzamidine to Obtain Specific Inhibitors of Group II sPLA2s.

✍ Francoise Heymans; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 10 KB