Viral-related DNA sequences before and after transformation by RNA tumor viruses
✍ Scribed by N. C. Goodman; R. M. Ruprecht; R. W. Sweet; R. Massey; F. Deinhardt; S. Spiegelman
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- French
- Weight
- 598 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Marmoset monkey fibroblasts transformed by non‐indigenous RNA tumor viruses (RSV or FeSV) acquire viral DNA sequences not present in normal cells. The newly gained sequences are always related to those of the transforming virus, a result in agreement with the proviral hypothesis. In contrast, the nucleic acid of the indigenous simian RNA tumor virus, SSV‐1, exhibits partial homology with the DNA of normal marmoset fibroblasts as well as with SSV‐1‐transformed cells. Since a similar situation has been observed with avian and lower mammalian systems, it would appear that homology with normal cellular DNA can be used to provide a tool for determining the species of origin of newly isolated RNA tumor viruses.