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Viral proliferating cell nuclear antigen

✍ Scribed by O'REILLY, DAVID R.; CRAWFORD, ALLAN M.; MILLER, LOIS K.


Book ID
109757937
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
119 KB
Volume
337
Category
Article
ISSN
0028-0836

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Proliferating cell nuclear antigen (PCNA), also known as a cofactor of DNA polymerase ␦, is required for eukaryotic cell DNA synthesis and nucleotide excision repair. Expression of PCNA gene is growth-regulated and UV inducible. In our previous study, we have observed that the rat PCNA promoter has