Viral load, physical status, and E6/E7 mRNA expression of human papillomavirus in head and neck squamous cell carcinoma
β Scribed by Zeyi Deng; Masahiro Hasegawa; Asanori Kiyuna; Sen Matayoshi; Takayuki Uehara; Shinya Agena; Yukashi Yamashita; Kazuhiko Ogawa; Hiroyuki Maeda; Mikio Suzuki
- Book ID
- 112097762
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 1002 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1043-3074
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## Abstract Freshβfrozen biopsies were obtained from 61 patients at diagnosis of squamous cell carcinoma of the head and neck (HNSCC) for study of the prevalence and physical status of human papillomavirus (HPV) DNA. The frequency of HPV DNA and genotypes were determined by SPF10 PCR screening with
Human papillomaviruses (HPVs) have been recognized as an essential pathogenic factor in anogenital cancer. HPV DNA has also been found in a subgroup of head-and-neck squamous-cell carcinomas (HNSCCs), and a causative role of the virus in the development of these tumors has been suggested by the conc
## Abstract The role of human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) development has been recognized only in the last decade. Although younger patients develop HNSCC associated with HPV, the incidence in young patients has not been studied. Fortyβfive young HNSCC pati