To determine the patient-dependent and virusrelated factors that may predict sustained response to interferon-a therapy, we prospectively evaluated 60 consecutive patients with chronic hepatitis C who received a standardized treatment schedule of interferon-a. Twenty-eight patients achieved a long-t
Viral, host and interferon-related factors modulating the effect of interferon therapy for hepatitis C virus infection
β Scribed by Ke-Qin Hu; John M. Vierling; Allan G. Redeker
- Book ID
- 108885651
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 227 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1352-0504
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Of 74 patients who were infected with hepatitis C virus (HCV) and received interferon, 12 (16%) were positive for RNA of GB virus C (GBV-C). RNA of GBV-C was determined in sera from the co-infected patients retrospectively, and the effect of interferon on GBV-C was compared with that on HCV in them.
## Abstract InterferonβΞ± (IFNβΞ±) has been used to treat hepatitis C Virus (HCV)βinduced infection but has been effective in only about half of all patients. It is suggested that the different responses to IFNβΞ± treatment in HCV infection may be influenced by HCV genotypes, HCV RNA titer at the begi