Viral evasion and subversion of pattern-recognition receptor signalling

✍ Scribed by Bowie, Andrew G.; Unterholzner, Leonie

• Book ID: 109955999
• Publisher: Nature Publishing Group
• Year: 2008
• Tongue: English
• Weight: 737 KB
• Volume: 8
• Category: Article
• ISSN: 1474-1741
• DOI: 10.1038/nri2436

✦ Synopsis

A host receptor (such as Toll-like receptors) that can sense pathogen-associated molecular patterns and initiate signalling cascades that lead to an innate immune response.
Endosome
An acidified intracellular vesicle that is derived from the plasma membrane. endosomes are involved in sorting endocytosed material before it is transported to lysosomes, and they are also the site of action for certain Toll-like receptors that sense viral nucleic acid.