Anti-viral drug treatment of infections with the human immunodeficiency virus type I (HIV-1) usually leads to a rapid decline in the abundance of plasma virus. The effect of single drug therapy, however, is often only short-lived as the virus readily develops drug-resistant mutants. In this paper we
β¦ LIBER β¦
Viral dynamics and anti-viral pharmacodynamics: rethinking in vitro measures of drug potency
β Scribed by Neil M Ferguson; Christophe Fraser; Roy M Anderson
- Book ID
- 117340476
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 74 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0165-6147
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## Abstract Conventional (static) models used in health economics implicitly assume that the probability of disease exposure is constant over time and unaffected by interventions. For transmissible infectious diseases this is not realistic and another class of models is required, soβcalled dynamic