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Viper venom neutralization by Indian medicinal plant (Hemidesmus indicus and Pluchea indica) root extracts

✍ Scribed by M. I. Alam; B. Auddy; A. Gomes

Book ID: 101285461
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 391 KB
Volume: 10
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199602)10:1<58::aid-ptr775>3.0.co;2-f

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✦ Synopsis

The methanol root extracts of Hemidesmus indicus R.Br. and Pluchea indica (Less) were explored for the first time for neutralization of snake venom (Viperu russellii) activity. The H . indicus and P . indica root extracts significantly neutralized the viper venom-induced lethality and haemorrhagic activity in albino rat and mouse. Venom-induced coagulant and anticoagulant activity was also antagonized by both the extracts. No precipitating bands were observed between the plant extract and polyvalent snake venom antiserum. Maximum neutralization was achieved by H. indicus root extract. These observations confirmed that certain Indian medicinal plants possess significant snake venom neutralizing capacity and need further examination for their active constituents.

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