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Viomycin resistance: Alterations of either ribosomal subunit affect the binding of the antibiotic to the pair subunit and the entire ribosome becomes resistant to the drug

โœ Scribed by Eung Chil Choi; Masarou Misumi; Toshio Nishimura; Nobuo Tanaka; Shinya Nomoto; Tadashi Teshima; Tetsuo Shiba

Book ID
118314157
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
438 KB
Volume
87
Category
Article
ISSN
0006-291X

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Binding of erythromycin to the 50S ribos
Binding of erythromycin to the 50S ribosomal subunit is affected by alterations in the 30S ribosomal subunit
โœ Saltzman, Larry ;Apirion, David ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Springer ๐ŸŒ English โš– 644 KB

Expression of resistance to erythromycin in Escherichia coli, caused by an altered L4 protein in the 50S ribosomal subunit, can be masked when two additional ribosomal mutations affecting the 30S proteins S5 and S12 are introduced into the strain (Saltzman, Brown, and Apriion, 1974). Ribosomes from