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Vinylogous Mannich Reactions. The Asymmetric Total Synthesis of (+)-Croomine

✍ Scribed by Martin, Stephen F.; Barr, Kenneth J.


Book ID
127001707
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
115 KB
Volume
118
Category
Article
ISSN
0002-7863

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πŸ“œ SIMILAR VOLUMES


ChemInform Abstract: Applications of Vin
✍ Stephen F. Martin; Kenneth J. Barr; Dudley W. Smith; Scott K. Bur πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 35 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

Vinylogous Mannich reactions. Stereosele
✍ Stephen F. Martin; Scott K. Bur πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 669 KB

A concise synthesis of (-)-3, a known precursor of pumiliotoxin 251D, has been completed using a vinylogous Mannich reaction as a key construction. Silyloxyfuran 10 added to methoxypyrrolidine 20 in the presence of TMS-OTf to give a mixture (4.8:1) of 21 and 22 in 57% yield. Reduction and global dep