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Vinyl phosphonates: A convenient route to phosphonic acid analogues of phosphate monoesters

✍ Scribed by T.L. Hullar

Publisher
Elsevier Science
Year
1967
Tongue
French
Weight
159 KB
Volume
8
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES

1-(Dihydroxyphosphynyl)vinyl phosphate:
1-(Dihydroxyphosphynyl)vinyl phosphate: The phosphonate analogue of phosphoenolpyruvate is a pH-dependent substrate of Kdo8P synthase
✍ Yaakov Benenson; Valery Belakhov; Timor Baasov πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 346 KB

The phosphonate analogue of PEP (structure 5), in which the carboxylate group is replaced by an isosteric phosphonate, was synthesized and evaluated as a substrate and as an inhibitor of the Kdo8P synthase. It was demonstrated that 5 is a very slow, pH-dependent substrate of the enzyme.