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Vinyl chloride and trichloroethylene: Comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liver

✍ Scribed by R. J. Laib; G. Stöckle; H. M. Bolt; W. Kunz

Book ID
112296897
Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
824 KB
Volume
94
Category
Article
ISSN
1432-1335

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The effects of cimetidine (CIM) (an inhibitor of the hepatic microsomal monooxygenase system) on the metabolism and hepatotoxicity of trichloroethylene (TRI) were studied in male Sprague-Dawley rats. Rats were given three doses of 120 mg/kg i.p. (low-dose regimen) of CIM at 0, 6 and 11 h for 1 day,