Vincristine treatment triggering the expression of asymptomatic Charcot-Marie-Tooth disease

✍ Scribed by Neumann, Yoram; Toren, Amos; Rechavi, Gideon; Seifried, Beth; Shoham, Nizza G.; Mandel, Mathilda; Kenet, Gilli; Sharon, Nechama; Sadeh, Menachem; Navon, Ruth

• Book ID: 101218209
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 368 KB
• Volume: 26
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199604)26:4<280::aid-mpo12>3.0.co;2-j

✦ Synopsis

A 16-year-old male suffering from Ewing's sarcoma of the pelvis was treated with vincristine as part of his chemotherapeutic protocol. The boy was never known to suffer from any neurological problems. His father had a mild limp, attributed to prolonged "taxi driving," that was never investigated medically. The first course of treatment, which included 2 mg of vincristine, resulted in clinical improvement. However, at the same time the patient developed severe weakness of both upper and lower limbs, areflexia, and gradually a pes caws deformity. Nerve conduction studies were suggestive of severe peripheral sensorimotor neuropathy, axonal and demyelinative. A definite diagnosis of Charcot-Marie-Tooth was confirmed by molecular analysis showing the typical duplication of 1.5 megabases at chromosome 17 p11.2. This unique manifestation of vincristine neurotoxicity is reported and discussed.

o 1996Wiley-Liss. Inc.