Vinca alkaloids. XXIX. Structure of leurosidine (vinrosidine, VRD), an oncolytic alkaloid from vinca rosea linn. (catharanthus roseus G. Don)
โ Scribed by Norbert Neuss; Lyell L. Huckstep; Nancy J. Cone
- Publisher
- Elsevier Science
- Year
- 1967
- Tongue
- French
- Weight
- 261 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The unique biological properties of leurosine (2), leurosidine (3), leurocristine (3) and vincaleukoblastine (4), dimeric indole-indoline alkaloids from Vinca rosea Linn. (Catharanthus roseus G. Don) have been -thoroughly reviewed (5). Two of these compound, leurocristine and vincaleukoblastine" have been introduced as therapeutically useful agents for the treatment of various human neoplasms.
๐ SIMILAR VOLUMES
Continuation of the phytochemical examination of this plant (1) which has produced two antitumor principles, vincaleukoblastine and leurosine, has yielded six previously unreported minor alkaloids in addition to those already reported from these laboratories (2). Details of the procedure leading to