Vimentin expression by reed-Sternberg cells in Hodgkin's disease
โ Scribed by Angel, Carole A. ;Cullen, Ronald A. ;Pringle, James H. ;Lauder, Ian
- Publisher
- Springer-Verlag
- Year
- 1992
- Tongue
- English
- Weight
- 456 KB
- Volume
- 421
- Category
- Article
- ISSN
- 0174-7398
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## Abstract There has been substantial advances in our understanding of the nature of the Hodgkin/ReedโSternberg (H/RS) cell in recent years. There is now compelling evidence that the H/RS cells in the vast majority of cases of classical Hodgkin's disease (CHD) are derived from the Bโcell lineage a
## Abstract EBV DNA has been detected by Southern blot hybridization in 20โ25% of Hodgkin's disease tumor specimens and localized to the ReedโSternberg cells by __in situ__ hybridization. In the present investigation we used a ^3^Hโlabelled EBER I antiโsense RNA for __in situ__ hybridization of arc
Hodgkin and Reed-Sternberg cells are considered to represent the malignant fraction in Hodgkin's disease. Several studies have shown that the Hodgkin and Reed-Sternberg cells are chromosomally abnormal, but genetic data about the morphologically normal cell population in Hodgkin's disease are very l