Vilsmeier—Haack Reaction on Hydrazones: A Convenient Synthesis of 4-Formylpyrazoles.
✍ Scribed by Karan Singh; Suman Ralhan; Pawan K. Sharma; Som N. Dhawan
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 16 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## InorgaIlia aoid halid@ kxC12, FCC+ &Cl3 and COC12) have heen reported to reset vith N,NUirsthylforuaalde (DMF) to form an aotire reagent, ohloromethylene diaethylammonium ahlorido (Vilweier-Raach reagent) (l), uhiah uaa initially found useful aa fornqlatlng, halogenating and dehydroxylating age
The reaction of a-hydroxyketenedithioacetals, generated by the 1,2-addition of methyl Grignard reagent to aoxoketenedithioacetals, with the Vilsmeier reagent was investigated. The reaction proceeds with acid-catalysed dehydration to afford sulphur substituted 1,3-butadienes, which undergo subsequent