Vilsmeier-haack reaction of 2H-1,4-benzoxazin-3-one: novel route for condensed benzoxazines
β Scribed by M. Mazharuddin; G. Thyagarajan
- Publisher
- Elsevier Science
- Year
- 1971
- Tongue
- French
- Weight
- 208 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Substituted 2β(benzylamino)β2__H__β1,4βbenzoxazinβ3(4__H__)βones are unstable under alkaline and acidic conditions, undergoing opening of the benzoxazinone ring. 2βBromoβ2__H__β1,4βbenzoxazinβ3(4__H__)βones show similar degradation under alkaline conditions, while replacement of Br at C
## Abstract The present review covers the synthesis and reactions of 2βheteroβ4__H__β3,1βbenzoxazinβ4βones which include oxygen, sulfur and nitrogen substituents. Literature coverage includes publications primarily from the mid 1960's to December 1999.
O-Acetates of 4-hydroxy and 4-hydroxy-7-methoxy-2H-1,4-benzoxazln-3-ones reacted with nucleophlles such as phenols, lndoles and ethanethlol The maJor reaction center IS the positively-charged nitrogen atom