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The amination of 3‐, 5‐, 6‐, 7‐ and 8‐nitroquinoline via the vicarious nucleophilic substitution of hydrogen (VNS) with 1,1,1‐trimethylhydrazinium iodide (TMHI) in the presence of t‐BuOK in DMSO was studied. The amination occurs regioselectively giving ortho or ortho and para isomers relative to the nitro group with a high yield (95‐86%). 2‐Nitroquinoline does not undergo vicarious amination but displacement of the labile nitro group by an amino group occurs and then transformation to an imine compound and hydrolysis gives2(1__H__)‐quinolinone.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydroxylation of azulenes with tert-butylhydroperoxide active nucleophile, also reacts with unsubstituted azulene. A variety of transformations of 6-hydroxyazulenes, such as proceeds efficiently at the 6-position when the former contain electron-withdrawing substituents in the five-substitution of t