## Abstract The reaction of methyl 2‐bromo‐6‐(trifluoromethyl)‐3‐pyridinecarboxylate (1) with methanesulfonamide gave methyl 2‐[(methylsulfonyl)amino]‐6‐(trifluoromethyl)‐3‐pyridine‐carboxylate (2). Alkylation of compound 2 with methyl iodide followed by cyclization of the resulting methyl 2‐[methy
Vibrational spectroscopy investigation using density functional theory on 7-chloro-3-methyl-2H-1,2,4- benzothiadiazine 1,1-dioxide
✍ Scribed by S. Seshadri; S. Gunasekaran; S. Muthu
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 144 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0377-0486
- DOI
- 10.1002/jrs.2176
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## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des
Tema~epam-2-'~C, 7-Chloro-1,3-ihydro-3-hydroxy-1 -methyl-5-phenyl-2H-1,4-benzodiazepin-2-one--"C, was prepared in a f ive-step synthesis. Chl~roacetic-l-~~C acid was converted to the acid chloride with thionyl chloride. The acid chloride was allowed to react with 2-methylamino-5-chloro-benzophenone
## Abstract 7‐Chloro‐1,3‐dihydro‐5‐(2‐fluorophenyl)‐1‐methyl‐2H‐1,4‐benzodiazepin‐2‐one (Fludiazepam) (I), an anti‐anxiety agent, was labelled with carbon‐14 at C‐5 position for metabolic studies. The reaction sequence for the synthesis is shown in Fig. 2. o‐Fluorobenzoic‐^14^C acid (IV) was prepar