✦ LIBER ✦
Viability thresholds for partial trisomies and monosomies. A study of 1,159 viable unbalanced reciprocal translocations
✍ Scribed by Olivier Cohen; Christine Cans; Marie-Ange Mermet; Jacques Demongeot; Pierre Jalbert
- Book ID
- 104666148
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 570 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
✦ Synopsis
From a data base of 1,590 independent families with autosomal reciprocal translocations, 1,159 viable unbalances were studied and the lengths of their trisomy/monosomy segments measured according to the method proposed by Daniel. About 5% of cases were found not to comply with Daniel viability criteria. The thresholds of viability vary with the mode of unbalance and with the sex of the carrier. Thus, new viability criteria are proposed as a guide for genetic counseling and prenatal diagnosis.