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VHL expression in renal cell carcinoma sensitizes to bortezomib (PS-341) through an NF-κB-dependent mechanism

✍ Scribed by An, Jiabin; Fisher, Myrna; Rettig, Matthew B

Book ID: 110069409
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 292 KB
Volume: 24
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1208348

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## We previously reported that chemokine Growth Regu lated Oncogene 1 (Gro 1) is over-expressed in murine squamous cell carcinoma (SCC) with metastatic tumor progression. The enhanced expression of Gro-1 gene by SCC is regulated by activation of nuclear factor-B (NF-B), leading to accelerated tumor