Veränderung der reninaktivität und des blutdruckverhaltens im autologen nierentransplantationsmodell am hund bei modifikation der HTK-lösung
✍ Scribed by A. Ludwig; F. E. Isemer; M. Kallerhoff; K. W. Rumpf
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 829 KB
- Volume
- 380
- Category
- Article
- ISSN
- 1435-2451
No coin nor oath required. For personal study only.
✦ Synopsis
Investigations of changes in activity of renin and blood pressure after reperfusion of the kidney transplant using HTK solution were carried out by means of an autologous, heterotopic model of kidney transplantation applied to dogs. Duration of cold ischemia was 48 h. According to variations in the composition of the HTK perfusion solution three test groups were set up. During the first 20 min after recirculation in each test group the renal venous and arterial renin activities were measured. Parallel to renin activity, the arterial blood pressure was recorded. During the first few minutes following recirculation of the kidney transplant the renin levels in the venous blood of the kidney were higher in test group 1 (HTK solution, perfusion height 120 cm) than in either of the other two, showing a median maximal increase of 195 ng/ml-h. In test group 2 the maximal venous renin concentration fell to 145 ng/ml.h, while graphs take a more uniform course. Test group 3 (HTK/tryptophan) differed from the others in having further improved renin values. After the 7.5 min of observation normal venous renin concentrations were measured following earlier values for maximal in-